Homologous recombination End resection

BRCA1

Breast cancer type 1 susceptibility protein

Short entry. It states only what the cited sources say; it will grow as more sources are read.

End resection

Breast cancer type 1 susceptibility protein

Plays a critical role in the competition between homologous recombination and NHEJ. In mouse cells lacking Brca1, 53BP1 partially blocks resection, and removing 53BP1 restores homologous recombination. [1][2]

In the pathway

References

  1. Symington & Gautier · 2011Double-strand break end resection and repair pathway choice
  2. Bunting et al. · 201053BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks
  3. Tan et al. · 2023Double-strand DNA break repair: molecular mechanisms and therapeutic targets
Read the HRD article

Pathway neighbours