Molecular diagnostics
Research
Studying how circulating tumour cells and tumour-derived DNA can reveal treatment response and resistance in ovarian cancer.
Current focus
Liquid biopsy in HGSOC
My doctoral work combines longitudinal ctDNA profiling, functional CTC phenotyping and evidence synthesis to investigate tumour evolution during PARP inhibitor maintenance therapy.
Interactive study
Following tumour evolution in blood
Can liquid biopsy reveal emerging treatment resistance before clinical relapse?
Dynamic circulating tumour cell phenotypes and ctDNA evolution during PARP inhibitor therapy in HGSOC
To longitudinally characterise functional CTC phenotypes and ctDNA molecular evolution during PARPi maintenance therapy.
Evidence synthesis
From published evidence to new experiments
A PROSPERO-registered systematic review and meta-analysis maps the evidence for circulating biomarkers in high-grade serous ovarian cancer.
Ongoing project
Liquid Biopsy Biomarkers in HGSOC
Systematic review and meta-analysis following a complete PRISMA workflow.
View projectWiki
The biology behind the research
DNA repair · HRD · PARP inhibitors
What is homologous recombination deficiency?
An illustrated introduction: follow DNA repair step by step, see where it can fail and how HRD is measured.
Research notes
Methods behind the research
HGSOC · RNA-seq · Reproducibility
PCA from first principles
A reproducible investigation of what drives variation in matched HGSOC RNA-seq data.