NHEJ Resolution
LIG4–XRCC4
DNA ligase IV – XRCC4
Short entry. It states only what the cited sources say; it will grow as more sources are read.
End joining
DNA ligase IV – XRCC4
The XRCC4–DNA ligase IV complex ligates the ends in NHEJ; XRCC4 stimulates the ligase. Ends that need it are first cut by Artemis with DNA-PKcs, or receive nucleotides from polymerases μ and λ. Junctions often contain mutations, although ends can also be joined with no loss or addition. [1]
- Interactions
- XRCC4, DNA-PKcs