Detection & signalling Sensing

MRE11

Meiotic recombination 11 homolog

Short entry. It states only what the cited sources say; it will grow as more sources are read.

End sensing

Meiotic recombination 11 homolog

Nuclease subunit of the MRN complex. Recombinant MRE11 has 3′→5′ exonuclease activity. With purified proteins, CtIP increased the endonuclease activity of the MRE11–RAD50 complex. [1][2]

Interactions
RAD50, CtIP

References

  1. Tan et al. · 2023Double-strand DNA break repair: molecular mechanisms and therapeutic targets
  2. Sartori et al. · 2007Human CtIP promotes DNA end resection
Read the HRD article