NHEJ End resection

Shieldin

Shieldin complex (REV7, SHLD1, SHLD2, SHLD3)

Short entry. It states only what the cited sources say; it will grow as more sources are read.

Anti-resection (NHEJ commitment)

Shieldin complex (REV7, SHLD1, SHLD2, SHLD3)

Protein complex that blocks DNA end resection. In pre-clinical experiments, its loss caused PARP-inhibitor resistance in BRCA1-mutant tumour cells. [1]

References

  1. Lord, Tutt & Ashworth · 2026Two decades of PARP inhibitor synthetic lethality in cancer
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