Detection & signalling Signalling
H2AX
Histone H2AX (phosphorylated on serine 139)
Short entry. It states only what the cited sources say; it will grow as more sources are read.
Kinase signalling & chromatin
Histone H2AX (phosphorylated on serine 139)
Histone H2A variant. Its serine 139 is phosphorylated by ATM, ATR or DNA-PK on the chromatin flanking a break, which leads to the recruitment of further DNA-damage response factors. [1]
- Interactions
- ATM
- In the pathway
- ATM activates it — phosphorylates serine 139, as do ATR and DNA-PK Jackson & Bartek · 2009
References
- Jackson & Bartek · 2009The DNA-damage response in human biology and disease