Detection & signalling Signalling
ATM
Ataxia-telangiectasia mutated
Short entry. It states only what the cited sources say; it will grow as more sources are read.
Kinase signalling & chromatin
Ataxia-telangiectasia mutated
Protein kinase recruited to double-strand breaks and activated there; in current models the MRN complex recruits and activates it. With its targets, including the kinase CHK2, it lowers CDK activity and slows the cell cycle. [1][2][3]
- Interactions
- CHK2
- In the pathway
- NBS1 activates it Tan et al. · 2023
- activates H2AX — phosphorylates serine 139, as do ATR and DNA-PK Jackson & Bartek · 2009
References
- Jackson & Bartek · 2009The DNA-damage response in human biology and disease
- Symington & Gautier · 2011Double-strand break end resection and repair pathway choice
- Tan et al. · 2023Double-strand DNA break repair: molecular mechanisms and therapeutic targets