Detection & signalling Sensing

NBS1

Nibrin (NBN)

Short entry. It states only what the cited sources say; it will grow as more sources are read.

End sensing

Nibrin (NBN)

Subunit of the MRN complex in mammalian cells. Its N-terminal FHA and BRCT domains bind phosphorylated proteins, and its C-terminal region facilitates the recruitment and activation of ATM. [1]

Interactions
ATM
In the pathway

References

  1. Tan et al. · 2023Double-strand DNA break repair: molecular mechanisms and therapeutic targets
Read the HRD article

Pathway neighbours