SSA / alt-EJ Resolution
MH deletions
Microhomology-mediated deletions
Short entry. It states only what the cited sources say; it will grow as more sources are read.
Process or outcome
Microhomology-mediated deletions
Microhomology-mediated end joining needs limited resection and always leaves deletions flanking the break. Some polymerase θ-mediated products also contain templated insertions. [1][2]
- Interactions
- POLθ
- In the pathway
- POLθ leads to it Ceccaldi et al. · 2015Chang et al. · 2017
References
- Symington & Gautier · 2011Double-strand break end resection and repair pathway choice
- Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
- Ceccaldi et al. · 2015Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair