SSA / alt-EJ Strand invasion & annealing
POLθ
DNA polymerase theta (POLQ)
Short entry. It states only what the cited sources say; it will grow as more sources are read.
Annealing (SSA / alt-EJ)
DNA polymerase theta (POLQ)
Error-prone polymerase that takes part in alternative end joining. It contains RAD51-binding motifs and blocks RAD51-mediated recombination. HR-deficient ovarian cancer cells were hypersensitive to its loss. [1]
- Interactions
- RAD51
- In the pathway
- CtIP leads to it — resection by MRN and CtIP also feeds alternative end joining Chang et al. · 2017Symington & Gautier · 2011
- leads to MH deletions Ceccaldi et al. · 2015Chang et al. · 2017
References
- Ceccaldi et al. · 2015Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair
- Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
- Symington & Gautier · 2011Double-strand break end resection and repair pathway choice