Detection & signalling Sensing

RAD50

RAD50 double-strand break repair protein

Short entry. It states only what the cited sources say; it will grow as more sources are read.

End sensing

RAD50 double-strand break repair protein

Subunit of the MRN complex with ABC ATPase motifs. A zinc hook joins two RAD50 molecules through four cysteine residues, two from each. [1]

In the pathway

References

  1. Tan et al. · 2023Double-strand DNA break repair: molecular mechanisms and therapeutic targets
  2. Symington & Gautier · 2011Double-strand break end resection and repair pathway choice
Read the HRD article

Pathway neighbours