The lesion Damage

DSB

DNA double-strand break

Short entry. It states only what the cited sources say; it will grow as more sources are read.

Process or outcome

DNA double-strand break

The phosphate backbones of both complementary DNA strands are broken. Ionising radiation can cause such breaks, and so can drugs that inhibit topoisomerases, such as etoposide; breaks also form when the replication machinery meets a single-strand break or certain other lesions. [1][2]

In the pathway

References

  1. Mehta & Haber · 2014Sources of DNA double-strand breaks and models of recombinational DNA repair
  2. Jackson & Bartek · 2009The DNA-damage response in human biology and disease
  3. Symington & Gautier · 2011Double-strand break end resection and repair pathway choice
  4. Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
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Pathway neighbours