NHEJ Sensing

KU70/80

Ku heterodimer (XRCC6 / XRCC5)

Short entry. It states only what the cited sources say; it will grow as more sources are read.

End joining

Ku heterodimer (XRCC6 / XRCC5)

Ring-shaped Ku70–Ku80 heterodimer with high affinity for DNA ends. It is abundant, which makes it likely to be the first protein to bind a broken end; it shields the ends, and extensive resection is prevented by Ku. [1][2]

In the pathway

References

  1. Tan et al. · 2023Double-strand DNA break repair: molecular mechanisms and therapeutic targets
  2. Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
  3. Symington & Gautier · 2011Double-strand break end resection and repair pathway choice
Read the HRD article

Pathway neighbours