SSA / alt-EJ Resolution

Repeat deletions

Single-strand annealing deletions

Short entry. It states only what the cited sources say; it will grow as more sources are read.

Process or outcome

Single-strand annealing deletions

Annealing between direct repeats leaves a deletion with a single copy of the repeat. The XPF–ERCC1 complex cuts the remaining 3′ overhangs before ligation. Single-strand annealing is described as nonconservative and prone to deletions and translocations. [1][2]

In the pathway

References

  1. Mehta & Haber · 2014Sources of DNA double-strand breaks and models of recombinational DNA repair
  2. Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
Read the HRD article

Pathway neighbours