Homologous recombination End resection
DNA2–BLM
DNA2 nuclease–helicase with BLM helicase
Short entry. It states only what the cited sources say; it will grow as more sources are read.
End resection
DNA2 nuclease–helicase with BLM helicase
The BLM helicase and the nuclease DNA2, acting as part of a complex, can also extend the 3′ tails created by MRN and CtIP. With purified proteins, other RecQ helicases could not substitute for BLM in the DNA2 reaction; in frog egg extracts the helicase is WRN. [1][2]
- Interactions
- CtIP
- In the pathway
- CtIP leads to it Chang et al. · 2017
- leads to RPA Chang et al. · 2017
References
- Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
- Symington & Gautier · 2011Double-strand break end resection and repair pathway choice