Homologous recombination End resection
RPA
Replication protein A (RPA1–3)
Short entry. It states only what the cited sources say; it will grow as more sources are read.
ssDNA & RAD51 filament
Replication protein A (RPA1–3)
Complex that binds single-stranded DNA: multiple copies cover the long 3′ tails. RPA-coated DNA also recruits the kinase ATR. RAD51 must then replace RPA; purified BRCA2 enables RAD51 to displace it. [1][2][3]
- Interactions
- BRCA2
- In the pathway
- EXO1 leads to it Chang et al. · 2017
- DNA2–BLM leads to it Chang et al. · 2017
- leads to RAD51 Jensen et al. · 2010Paliwal et al. · 2014
References
- Chang et al. · 2017Non-homologous DNA end joining and alternative pathways to double-strand break repair
- Sartori et al. · 2007Human CtIP promotes DNA end resection
- Jensen et al. · 2010Purified human BRCA2 stimulates RAD51-mediated recombination
- Paliwal et al. · 2014Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing