Homologous recombination Strand invasion & annealing
RAD51
RAD51 recombinase
Short entry. It states only what the cited sources say; it will grow as more sources are read.
ssDNA & RAD51 filament
RAD51 recombinase
Recombinase that assembles on single-stranded DNA as a nucleoprotein filament and catalyses the invasion and exchange of homologous DNA sequences. [1]
- In the pathway
- BRCA2 recruits it — enables RAD51 to displace RPA (purified proteins) Jensen et al. · 2010
- RPA leads to it Jensen et al. · 2010Paliwal et al. · 2014
- leads to Strand invasion Paliwal et al. · 2014
References
- Jensen et al. · 2010Purified human BRCA2 stimulates RAD51-mediated recombination
- Paliwal et al. · 2014Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing